様 - さま - (Polite language) Mr, Mrs or Ms, Lord
かも - Duck (this is the literal meaning, but it is often used to mean an easy target, sucker or sitting duck)
です - Polite copula in Japanese (this roughly means "is, be, are, am". It is very common in Japanese and usually put at the end of a statement)
よ - (At sentence end) indicates certainty or emphasis (within this context)
なに - What
ひさしぶり - A long time (since the last time, within this context)
の - Indicates possessive and nominalizes verbs and adjectives
獲物 - えもの - Game, spoils, trophy, prey
だ - Polite copula in Japanese (だ here is the informal version of です)
な - (Sentence end, mainly masculine) indicates casual emphasis on a decision, suggestion or opinion (within this context)
ふふ - Giggling sound; laugh; ha ha
Mr. Yamcha!! It's a sitting duck! A sitting duck!
What!? It's (the first ) prey in a long time...ha ha...